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Immunotherapy

Immunotherapy harnesses the body’s natural immune system to identify and destroy cancerous cells. It encompasses a range of treatments, some designed to enhance the immune system’s overall effectiveness and others tailored to target specific cancerous cells within tumors.

Key Treatment: Immune Checkpoint Inhibitors

Immune checkpoint inhibitors are a pivotal immunotherapy approach. These treatments help the immune system combat cancers like lung cancer and melanoma by blocking certain proteins that prevent T cells (a type of immune cell) from attacking cancer cells effectively.

Alternate Names: Monoclonal Antibodies
Body Location: Immune System
Procedure Type: Intravenous Administration

Preparing for Immune Checkpoint Inhibitor Treatment

Before beginning treatment, patients should follow these guidelines:

  • Allergy Disclosure: Notify the physician about any known allergies to prescribed medications.
  • Blood Tests: Required before each treatment session.
  • Medication Interactions: Inform your doctor about any other medications being taken, as some may interact with the treatment.
  • Reproductive Considerations: Use contraception during treatment and for at least five months after the final dose to prevent harm to unborn children.
  • Breastfeeding: Avoid breastfeeding during the treatment period.
  • Professional Notification: Ensure all healthcare providers (e.g., dentists) are aware of your ongoing treatment.

Procedure Overview

Checkpoint inhibitors work by targeting specific proteins on T cells, the immune system’s disease-fighting cells. In a healthy body, these proteins help regulate T cell activity—turning them on to attack infections and turning them off to prevent damage to healthy cells. However, some cancers exploit this system by producing proteins that deactivate T cells, allowing the cancer to grow unchecked.

Checkpoint inhibitors block these proteins, reactivating T cells to attack and destroy cancerous cells.

Treatment Details:

  • Administered intravenously (through a vein in the arm).
  • Sessions typically last 30 to 90 minutes and occur every two to four weeks.
  • The number of sessions varies depending on the type of cancer and prescribed drugs.

Post-Treatment Recovery

After undergoing immune checkpoint inhibitor therapy:

  • Tumor reduction is often observed within 18–24 months, depending on the cancer type and treatment.
  • Follow-up care includes regular appointments, blood tests, and imaging (e.g., CT scans).
  • Caregivers must maintain hygiene, especially when handling the patient’s body fluids.
  • Nutrition adjustments, such as incorporating high-fiber foods, may improve treatment outcomes.

Common Post-Treatment Concerns:

  • Diabetes
  • Hepatitis
  • Hypophysitis (inflammation of the pituitary gland)
  • Myocarditis (heart inflammation)
  • Nephritis (kidney inflammation)

Follow-Up Care

Immune checkpoint inhibitor sessions are outpatient procedures. After treatment:

  • Patients may be observed briefly before discharge.
  • It’s advisable to have someone accompany the patient to assist with transportation if fatigue occurs.

Risks and Side Effects

  1. Common Side Effects:

  • Rash
  • Diarrhea
  • Fatigue
  • Nausea
  • Poor appetite
  • Joint pain and numbness 

Rare but Serious Risks:

  1. Infusion Reactions: Allergic responses like fever, chills, dizziness, and wheezing during drug administration.
  2. Autoimmune Reactions: The immune system may attack healthy tissues, causing complications in organs such as the lungs, intestines, and liver. These reactions are typically managed with corticosteroids.

 

Immunotherapy, particularly immune checkpoint inhibitors, represents a groundbreaking advancement in cancer treatment, empowering the body’s natural defenses to fight back against cancerous cells. Patients are encouraged to maintain open communication with their healthcare teams to ensure optimal treatment outcomes.

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